Research

At Advanced Genomics through our dedication to innovative and scientific excellence, we have developed two pipelines:

  • Research and Discovery
  • Complete Solution

Research and Discovery:

Early research which encompasses the entire spectrum of genomic biomarkers discovery, predictive diagnostics, development of DNA based clinical diagnostics and analysis of drug response and drug toxicity.

Complete solution:

Advanced Genomics offers complete solutions right across the value chain, from identification of lead candidates to gene testing. Our expert personnel are specialized in wide range of services that start form wet lab basic research to microarray experimental procedures, data acquisition and analysis, bioinformatics, and database management.

Advanced Genomics in Medicine- AdGen Medical TM

Advanced Genomics has developed technology that unlocks secrets of genes and raking in the big bucks for the development of better diagnostics, safe and cost effective drugs and personalized treatment procedures. Our product development pipeline includes early research which encompasses the entire spectrum of genomic biomarkers discovery, predictive diagnosis, and analysis of drug response and drug toxicity. The development phase of this pipeline will slowly expand to drug discovery and development of DNA based clinical diagnostics.

Our unique and powerful genomics and bioinformatics tools and database are designed to characterize disease pathways and identify lead candidates for biomarker discovery of chronic diseases like cancers, as well as emerging and re-emerging infectious diseases.

Disease Pathway

Biomarker Discovery

Fighting with Infectious diseases: Infectious diseases remain the leading cause of death worldwide despite advances in medical research. Globalization, increasing trade, changes in human demographics, behavior, etc. bring people into closer and more frequent contact with pathogens. These changing trends remain the leading causes of the emergence and reemergence of infectious diseases. Improper use of antibiotics has led to the development of resistant pathogens that are untreatable with standard treatment protocols.

Advanced genomics is collaborating on a global level with hospitals and research institutes to identify better control strategies by using genomics and post-genomics research. With two decades of experience of characterizing various pathogens and host-pathogen interactions at the molecular level, Advanced Genomics is well positioned to rapidly deploy its proven technology to respond to the prevention of infectious diseases. Our main focus of research is on Zoonotic diseases and will slowly expand to other areas. Technology developed by Advanced Genomics is being used to get following information:

  • Gene expression signatures of various pathogens within the host and then comparison of those signatures.
  • Genomic content of various strains is compared to reference strain to identify conservation of virulence genes among various strains indicate that pathogen possesses the basic pathogenic mechanism that confers an opportunistic infection capability
  • Whole-genome expression analysis in virulent and avirulent strains is performed to identify differentially expressed defense genes and pathogen genes in host.
  • Sequencing and post-genomic research of emerging disease agents/vectors, to reveal genetic basis for microbial/vector evolution, adaptation, and pathogenicity
  • Gene expression signatures to study host-pathogen interaction and mechanism of virulence
  • Whole-genome expression analysis to view complete progression of an infectious disease state

Advanced Genomics in Pharmacogenomics- AdGen PharmaTM

Many commonly used drugs are effective for only 40 to 60% of the patient population, up to 15% of hospitalized patients experience serious adverse drug reactions and more than 100,000 deaths occur annually as a result of such reactions. Patients with the most common cancers like brain tumors, breast cancers and leukemia, receive very aggressive treatments and often have serious side effects and very often are not effective. The very same medicine that works wonders for some people can be ineffective or even toxic to others. The reason for this is that as medicine finds its way to the target site in the body, so many things happen along the way. One reaction triggers another and medicine that should work, masks the symptom. An individual’s metabolism also plays a big role. Every individual metabolizes drugs differently. Variations (SNPs) in the genes of an individual make different proteins and as a drug travels through the body, it interacts with many of these proteins. Genomic research in drug discovery has paved the way for targeted therapies and personalized medicine. Genetic variations affect the metabolism and pharmacological activity of drugs. Advanced Genomics at Research and Discovery Platform.

Advanced Genomics at Research and Discovery Platform is using SNPs and gene expression analysis for:

  • Assessment of drug toxicity and efficacy
  • Selection of lead candidate for drug discovery
  • Development and screening of compounds through cell based and biochemical assays
  • Sort out the patients best suitable for particular drug and therapy

 

Advanced Genomics at Complete Solution Platform:Advanced Genomics provides a platform for the development of tools for early diagnosis of certain conditions and for identifying molecular targets for therapeutic interventions. Advanced Genomics is working with partners for developing some of the pharmacogenomics tests for the prevention and assessment of drug treatment and therapy.

Prognostic and Diagnostic Biomarkers Discovery: At Advanced Genomics, we use gene expression signatures to explore the underlying biology of a disease or drug response, to understand the various mechanisms and manifestations of disease.

Theranostic Biomarkers Discovery: We also identify biomarkers in monitoring response to therapy. We use gene expression study to stratify patients into groups likely to respond to the mechanism of therapy and to distinguish responders from non-responders to therapy.

Advanced Genomics in Environment- AdGen-Enviro TM

 

Increasing pollution of water and soil by xenobiotic compounds has tremendous effects on human health as some of them are recalcitrant.

There is acute need for understanding the impact of toxic compounds on humans as well as on other microbial populations. Forests, which provide enormous possibilities to improve human health are challenged by ecosystem, biodiversity degradation and increasing number of insects and microbial pathogens. Advanced Genomics with the support of partners is trying to develop new and innovative strategies to be used in prevention programs from the standpoint of environmental technology and health.

Advanced Genomics is using high-throughput approaches such as microarrays and metagenomics in pollution abatement and environment management by focussing.

Advanced Genomics in Nutrition- AdGen-NutriTM

Diet, genes and environment interact and affect health outcome. Most common diseases such as diabetes, obesity, heart disease and some cancers are the result of diet intake in combination with genetic variations. By eating a certain diet, one can turn genes on or off. Studies have shown that by eating omega-3s diet , specifically EPA and DHA, can alter gene expression to a more anti-inflammatory and anti-atherogenic status. Advanced Genomics is committed to disease prevention and total health by taking proactive approaches. The central focus of Advanced Genomics study is nutrigenomics (nutrition + genomics). This will bring new insights into human health and will have a significantly positive impact on our quality of life.

Research and Discovery:

Advanced Genomics and its partners are studying the interaction of nutrients with human DNA. Genetic code affects the need for certain nutrients. Developing personalized nutrition solutions according to individual DNA make up can help maintain optimal health throughout your life. Advanced Genomics is doing cutting edge research by using technologies such as Microarrays, miRNAs, genotyping, SNPs, sequencing and Genome Wide Association studies to:

  • Identify differential gene expression by phytonutrients
  • Determine relationship between diet and epigenetic phenomenon
  • Develop probiotic and prebiotic approaches for the improvement of functional foods
  • Determine molecular basis of biodiversity in seeds
  • Identify tools for prognosis/diagnosis and QC of milk and dairy products
  • Detecting animal health status, and breeding conditions

 

Complete Solution:

  • Determine individual genetic predisposition
  • Identify genetic variations that influence health status
  • Determine influence of certain diets and high risk behavior (alcohol abuse, and tobacco smoking) on gene expression, transcription, protein expression and metabolism
  • Modulate the expression of diseased genes by taking diet rich in omega 3s, reserveratrol, vitamin B12, and vitamin C
  • Identify genetic variations for nutrition and diet susceptibility
  • Create solutions for personalized nutrition to prevent diseases

Disease PathwayBiomarker Discovery

Fighting with Infectious diseases: Infectious diseases remain the leading cause of death worldwide despite advances in medical research. Globalization, increasing trade, changes in human demographics, behavior, etc. bring people into closer and more frequent contact with pathogens. These changing trends remain the leading causes of the emergence and reemergence of infectious diseases. Improper use of antibiotics has led to the development of resistant pathogens that are untreatable with standard treatment protocols.

Advanced genomics is collaborating on a global level with hospitals and research institutes to identify better control strategies by using genomics and post-genomics research. With two decades of experience of characterizing various pathogens and host-pathogen interactions at the molecular level, Advanced Genomics is well positioned to rapidly deploy its proven technology to respond to the prevention of infectious diseases. Our main focus of research is on Zoonotic diseases and will slowly expand to other areas. Technology developed by Advanced Genomics is being used to get following information:

  • Gene expression signatures of various pathogens within the host and then comparison of those signatures.
  • Genomic content of various strains is compared to reference strain to identify conservation of virulence genes among various strains indicate that pathogen possesses the basic pathogenic mechanism that confers an opportunistic infection capability
  • Whole-genome expression analysis in virulent and avirulent strains is performed to identify differentially expressed defense genes and pathogen genes in host.
  • Sequencing and post-genomic research of emerging disease agents/vectors, to reveal genetic basis for microbial/vector evolution, adaptation, and pathogenicity
  • Gene expression signatures to study host-pathogen interaction and mechanism of virulence
  • Whole-genome expression analysis to view complete progression of an infectious disease state